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Find All Shortest Reaction Paths

Usage

find_all_shortest_paths(
  napistu_list,
  source_species_id,
  dest_species_id,
  weights_var = "weights"
)

Arguments

napistu_list

A list containing loaded assets and bindings to Python modules.

sbml_dfs

SBML_dfs - the core pathway representation of the Napistu Python library

napistu_graph

Network graph - a Python igraph subclass with Napistu-specific attributes and methods

species_identifiers

Species identifier mappings

precomputed_distances

optional, distances between species nodes

species_names

A tibble containing the names of all genes, proteins, molecules, etc

identifiers_nest

A tibble with one row per ontology and a nested tibble containing all the identifiers and their corresponding molecular species

python_modules

A named list of Python modules: `napistu`

python_environment

See validate_python_environment

napistu_config

A `napistu_config` object dictating how the `napistu_list` was initialized

loaded_at

A date-time object indicating when `napistu_list` was initialized

source_species_id

species ID of the upstream/source vertex

dest_species_id

species ID of the downstream/destination vertex

weights_var

variable in edges to use for edge weights

Value

All the shortest paths between `source_species_id` and `dest_species_id`

Examples

setup_napistu_list(create_napistu_config())
#> 
#> ── Setting up Napistu environment ──────────────────────────────────────────────
#> No Python configuration specified, setting up conda environment
#> Using existing conda environment "napistu-config"
#> Python version 3.11 meets requirements
#> No assets configuration specified, loading bundled package data
#> Loading sbml_dfs from sbml_dfs.pkl
#> Error in value[[3L]](cond): Failed to load sbml_dfs from
#> /home/runner/work/_temp/Library/napistu.r/extdata/test_pathway/sbml_dfs.pkl:
#> ImportError: /usr/lib/x86_64-linux-gnu/libcrypto.so.3: version `OPENSSL_3.3.0'
#> not found (required by
#> /usr/share/miniconda/envs/napistu-config/lib/python3.11/lib-dynload/_ssl.cpython-311-x86_64-linux-gnu.so)
#> Run `reticulate::py_last_error()` for details.
source_species_id <- random_species(napistu_list)
#> Error: object 'napistu_list' not found
dest_species_id <- random_species(napistu_list)
#> Error: object 'napistu_list' not found
find_all_shortest_paths(napistu_list, source_species_id, dest_species_id)
#> Error: object 'napistu_list' not found